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Forschung

Forschungs- und Arbeitsschwerpunkte der Professur Ernährungsphysiologie

Key Research Interests and Expertise


• cardiometabolic effects of dietary fat, especially of plant and marine omega-3 fatty acids
• bioavailability, metabolism and cardiometabolic effects of polyphenols (e.g., quercetin, catechins, xanthohumol)
• postprandial metabolism and determinants
• cardiometabolic effects of dietary patterns
• nutrient-genotype interactions with a focus on the APOE genotype
• risk phenotypes for cardiovascular and neurodegenerative diseases

 

Main Methods Focus


• human intervention trials including (strictly) controlled dietary studies (iso- or hypoenergetic), placebo-controlled trials (RCTs), postprandial protocols and bioavailability studies
• study subjects are e.g. metabolically healthy participants and subjects with a risk phenotype for cardiovascular and neurodegenerative disease

 

Selected Projects

Effects of canola oil and coconut oil on postprandial metabolism


The aim of this study is to investigate the postprandial effects of fat content and fatty acid composition of mixed meals enriched with canola oil or coconut oil on parameters associated with cardiometabolic and neurodegenerative diseases in older adults.

ClinicalTrials.gov ID: NCT05208346

 

Acute effects of different meals on postprandial metabolism in elderly men and women with a risk phenotype for cardiovascular diseases


There is increasing evidence that the postprandial state is an important contributing factor to chronic diseases. The postprandial situation is generally characterized by hyperlipemia, hyperglycaemia/insulinaemia, and associated events such as low-grade oxidative stress and inflammation. The physiology and pathophysiology of the postprandial responses are influenced by nutrient-independent (e.g., metabolic diseases) and nutrient-dependent (e.g., energy content of a meal) factors. The aim of this research project was to systematically investigate the effects of different meals on postprandial metabolic events and to identify dietary, physiological and genetic determinants of postprandial reactions. The study was supported by the German Federal Ministry of Education and Research (BMBF) within the project “Diet-Body-Brain” (grant no. 01EA1372D).

DRKS-ID: DRKS00009861

 

Acute impact of dietary pattern and walking on postprandial metabolism, attention, and mood in older adults with a cardiovascular disease risk phenotype


Attenuating the postprandial stress response and its associated inflammatory and endothelial events through specific nutritional and lifestyle interventions seems to be a promising and important approach to decrease the susceptibility to the development of cardiovascular diseases in the long term. This might be particularly relevant in individuals already at increased risk to develop cardiovascular or neurodegenerative complications (e.g., individuals with metabolic syndrome). This research project followed a holistic approach and examined the effects of meal composition and moderate physical activity on postprandial events in older subjects with increased risk for the development of cardiovascular and neurodegenerative diseases.

DRKS-ID: DRKS00012409

 

Bioavailability of quercetin in healthy men and women


The flavonol quercetin is one of the major flavonoids found in edible plants. The bioavailability of quercetin in humans may be influenced by the food matrix in which it is consumed as well as by its chemical and physical form. The objective of this study was to investigate the systemic availability of quercetin aglycone from hard capsules filled with onion skin extract powder and from hard capsules filled with pure quercetin dihydrate, in metabolically healthy normal-weight men and women. A secondary objective was to examine potential sex-specific differences in the bioavailability of quercetin.

DRKS-ID: DRKS00004350

 

Human intervention study to examine interactions between alpha-linolenic acid and quercetin


Increased dietary intake and tissue status of the long-chain n-3 PUFA, EPA and DHA, is associated with cardiovascular benefits. Epidemiological and animal studies suggest that concomitant nutritive intake of flavonoids (e.g., quercetin) may increase the conversion of α-linolenic acid (ALA) to longer-chain n-3 fatty acids EPA and DHA. This research project investigated the effects of increased ALA intake on fatty acid composition of serum phospholipids and erythrocytes in metabolically healthy men and women and whether fatty acid profiles and ALA conversion were affected by regular quercetin intake or sex. In addition, the potential independent and additive effects of plant ALA and quercetin on markers of cardiovascular disease risk (e.g., blood pressure, lipid and glucose metabolism, inflammation) were examined.

DRKS-ID: DRKS00005076

 

Effects of quercetin on blood pressure and endothelial function in subjects with a high CVD risk phenotype


The aim of this project was to investigate the effects of dietary quercetin supplementation on blood pressure parameters, direct and indirect biomarkers of endothelial function, as well as biomarkers of oxidation and inflammation in patients with characteristics of a metabolic syndrome. To this end, a double-blinded, placebo-controlled crossover trial in overweight men and women was conducted (Grant No. EG292/3-1 of the German Research Foundation (DFG)).

DRKS-ID: DRKS00000555

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